| Ron Klain | Chief of Staff |
| Janet Yellen | Secretary of Treasury |
| Alejandro Mayorkas | Secretary of Homeland Security |
| Tony Blinken | Secretary of State |
| Merrick Brian Garland | Attorney General |
| Jared Bernstein | Council of Economic Advisors |
| Rochelle Walensky | Director of the Centers for Disease Control and Prevention |
| Wendy Sherman | Deputy Secretary of State |
| Anne Neuberger | Deputy National Security Adviser for Cybersecurity |
| Jeffrey Zients | COVID-19 Response Coordinator |
| David Kessler | Co-chair of the COVID-19 Advisory Board and Head of Operation Warp Speed |
| David Cohen | CIA Deputy Director |
| Rachel Levine | Deputy Health Secretary |
| Jennifer Klein | Co-chair Council on Gender Policy |
| Jessica Rosenworcel | Chair of the Federal Communications Commission |
| Stephanie Pollack | Deputy Administrator of the Federal Highway Administration |
| Polly Trottenberg | Deputy Secretary of Transportation |
| Avril Haines | Director of National Intelligence |
| Eric Lander | Office of Science and Technology Policy director |